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KCML: a machine‐learning framework for inference of multi‐scale gene functions from genetic perturbation screens

Characterising context‐dependent gene functions is crucial for understanding the genetic bases of health and disease. To date, inference of gene functions from large‐scale genetic perturbation screens is based on ad hoc analysis pipelines involving unsupervised clustering and functional enrichment....

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Detalles Bibliográficos
Autores principales: Sailem, Heba Z, Rittscher, Jens, Pelkmans, Lucas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059140/
https://www.ncbi.nlm.nih.gov/pubmed/32141232
http://dx.doi.org/10.15252/msb.20199083