Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin

ERCC1 (excision repair cross complementing‐group 1) is a mammalian endonuclease that incises the damaged strand of DNA during nucleotide excision repair and interstrand cross‐link repair. Ercc1(−/Δ) mice, carrying one null and one hypomorphic Ercc1 allele, have been widely used to study aging due to...

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Detalles Bibliográficos
Autores principales: Kim, Dong Eun, Dollé, Martijn E. T., Vermeij, Wilbert P., Gyenis, Akos, Vogel, Katharina, Hoeijmakers, Jan H. J., Wiley, Christopher D., Davalos, Albert R., Hasty, Paul, Desprez, Pierre‐Yves, Campisi, Judith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059167/
https://www.ncbi.nlm.nih.gov/pubmed/31737985
http://dx.doi.org/10.1111/acel.13072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059167/
https://www.ncbi.nlm.nih.gov/pubmed/31737985
http://dx.doi.org/10.1111/acel.13072

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