Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity

The accumulation of senescent cells (SnCs) is a causal factor of various age‐related diseases as well as some of the side effects of chemotherapy. Pharmacological elimination of SnCs (senolysis) has the potential to be developed into novel therapeutic strategies to treat these diseases and pathologi...

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Detalles Bibliográficos
Autores principales: He, Yonghan, Li, Wen, Lv, Dongwen, Zhang, Xin, Zhang, Xuan, Ortiz, Yuma T., Budamagunta, Vivekananda, Campisi, Judith, Zheng, Guangrong, Zhou, Daohong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059172/
https://www.ncbi.nlm.nih.gov/pubmed/32064756
http://dx.doi.org/10.1111/acel.13117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059172/
https://www.ncbi.nlm.nih.gov/pubmed/32064756
http://dx.doi.org/10.1111/acel.13117

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