Inhibition of BACE1, the β-secretase implicated in Alzheimer’s disease, by a chondroitin sulfate extract from Sardina pilchardus

The pharmaceutical and anticoagulant agent heparin, a member of the glycosaminoglycan family of carbohydrates, has previously been identified as a potent inhibitor of a key Alzheimer’s disease drug target, the primary neuronal β-secretase, β-site amyloid precursor protein cleaving enzyme 1 (BACE1)....

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Detalles Bibliográficos
Autores principales: Mycroft-West, Courtney J., Devlin, Anthony J., Cooper, Lynsay C., Procter, Patricia, Miller, Gavin J., Fernig, David G., Guerrini, Marco, Guimond, Scott E., Lima, Marcelo A., Yates, Edwin A., Skidmore, Mark Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059579/
https://www.ncbi.nlm.nih.gov/pubmed/31997821
http://dx.doi.org/10.4103/1673-5374.274341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059579/
https://www.ncbi.nlm.nih.gov/pubmed/31997821
http://dx.doi.org/10.4103/1673-5374.274341

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