Cargando…
SEPT9_v2, frequently silenced by promoter hypermethylation, exerts anti-tumor functions through inactivation of Wnt/β-catenin signaling pathway via miR92b-3p/FZD10 in nasopharyngeal carcinoma cells
BACKGROUND: Nasopharyngeal carcinoma tends to present at an advanced stage because the primary anatomic site is located in a less visible area and its clinical symptoms are nonspecific. Prognosis of advanced nasopharyngeal carcinoma cases remains disappointing. SEPT9 is a methylation-based biomarker...
Autores principales: | Jiang, Yu, Liu, Lei, Xiang, Qin, He, Xiaoqian, Wang, Yan, Zhou, Dishu, Zou, Can, Chen, Qian, Peng, Mingyu, He, Jin, Jiang, Xianyao, Xiang, Tingxiu, Yang, Yucheng |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059696/ https://www.ncbi.nlm.nih.gov/pubmed/32138771 http://dx.doi.org/10.1186/s13148-020-00833-5 |
Ejemplares similares
-
TET1 exerts its anti-tumor functions via demethylating DACT2 and SFRP2 to antagonize Wnt/β-catenin signaling pathway in nasopharyngeal carcinoma cells
por: Fan, Jiangxia, et al.
Publicado: (2018) -
The new 6q27 tumor suppressor DACT2, frequently silenced by CpG methylation, sensitizes nasopharyngeal cancer cells to paclitaxel and 5-FU toxicity via β-catenin/Cdc25c signaling and G2/M arrest
por: Zhang, Yan, et al.
Publicado: (2018) -
KRAB zinc-finger protein 382 regulates epithelial-mesenchymal transition and functions as a tumor suppressor, but is silenced by CpG methylation in gastric cancer
por: Pei, Lijiao, et al.
Publicado: (2018) -
TFPI-2 is a putative tumor suppressor gene frequently inactivated by promoter hypermethylation in nasopharyngeal carcinoma
por: Wang, Shumin, et al.
Publicado: (2010) -
Putative tumour-suppressor gene DAB2 is frequently down regulated by promoter hypermethylation in nasopharyngeal carcinoma
por: Tong, Joanna H, et al.
Publicado: (2010)