Novel Chemical Scaffolds to Inhibit the Neutral Amino Acid Transporter B(0)AT1 (SLC6A19), a Potential Target to Treat Metabolic Diseases

Lack of B(0)AT1 (SLC6A19) partially protects mice against the onset of non-alcoholic steatohepatitis (NASH). To achieve a similar outcome through pharmacological treatment, we improved previously identified inhibitors of B(0)AT1 by medicinal chemistry and identified second generation inhibitors by h...

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Detalles Bibliográficos
Autores principales: Yadav, Aditya, Shah, Nishank, Tiwari, Praveen Kumar, Javed, Kiran, Cheng, Qi, Aidhen, Indrapal Singh, Bröer, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059793/
https://www.ncbi.nlm.nih.gov/pubmed/32180718
http://dx.doi.org/10.3389/fphar.2020.00140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059793/
https://www.ncbi.nlm.nih.gov/pubmed/32180718
http://dx.doi.org/10.3389/fphar.2020.00140

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