LY354740 Reduces Extracellular Glutamate Concentration, Inhibits Phosphorylation of Fyn/NMDARs, and Expression of PLK2/pS129 α-Synuclein in Mice Treated With Acute or Sub-Acute MPTP

Glutamate overactivity in basal ganglia critically contributes to the exacerbation of dopaminergic neuron degeneration in Parkinson’s disease (PD). Activation of group II metabotropic glutamate receptors (mGlu(2/3) receptors), which can decrease excitatory glutamate neurotransmission, provides an op...

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Detalles Bibliográficos
Autores principales: Tan, Yang, Xu, Yan, Cheng, Chi, Zheng, Cong, Zeng, Weiqi, Wang, Ji, Zhang, Xiaoqian, Yang, Xiaoman, Wang, Jialing, Yang, Xiaomei, Nie, Shuke, Cao, Xuebing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059821/
https://www.ncbi.nlm.nih.gov/pubmed/32180729
http://dx.doi.org/10.3389/fphar.2020.00183

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059821/
https://www.ncbi.nlm.nih.gov/pubmed/32180729
http://dx.doi.org/10.3389/fphar.2020.00183

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