The Immunomodulator 1-Methyltryptophan Drives Tryptophan Catabolism Toward the Kynurenic Acid Branch

Background: Animal model studies revealed that the application of 1-methyltryptophan (1-MT), a tryptophan (TRP) analog, surprisingly increased plasma levels of the TRP metabolite, kynurenic acid (KYNA). Under inflammatory conditions, KYNA has been shown to mediate various immunomodulatory effects. T...

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Detalles Bibliográficos
Autores principales: Wirthgen, Elisa, Leonard, Anne K., Scharf, Christian, Domanska, Grazyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059861/
https://www.ncbi.nlm.nih.gov/pubmed/32180772
http://dx.doi.org/10.3389/fimmu.2020.00313

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059861/
https://www.ncbi.nlm.nih.gov/pubmed/32180772
http://dx.doi.org/10.3389/fimmu.2020.00313

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