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In silico investigation of the mechanisms underlying atrial fibrillation due to impaired Pitx2

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is a major cause of stroke and morbidity. Recent genome-wide association studies have shown that paired-like homeodomain transcription factor 2 (Pitx2) to be strongly associated with AF. However, the mechanisms underlying P...

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Detalles Bibliográficos
Autores principales: Bai, Jieyun, Lo, Andy, Gladding, Patrick A., Stiles, Martin K., Fedorov, Vadim V., Zhao, Jichao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059955/
https://www.ncbi.nlm.nih.gov/pubmed/32097431
http://dx.doi.org/10.1371/journal.pcbi.1007678