Loss of HNF1α Function Contributes to Hepatocyte Proliferation and Abnormal Cholesterol Metabolism via Downregulating miR-122: A Novel Mechanism of MODY3

PURPOSE: Mutations in hepatocyte nuclear factor 1α (HNF1α) are the cause of maturity-onset diabetes of the young type 3 (MODY3) and involved in the development of hepatocellular adenoma and abnormal lipid metabolism. Previously, we have found that the serum microRNA (miR)-122 levels in MODY3 patient...

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Detalles Bibliográficos
Autores principales: Hu, Mengdie, Huang, Xiuting, Han, Xueyao, Ji, Linong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060037/
https://www.ncbi.nlm.nih.gov/pubmed/32184642
http://dx.doi.org/10.2147/DMSO.S236915

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060037/
https://www.ncbi.nlm.nih.gov/pubmed/32184642
http://dx.doi.org/10.2147/DMSO.S236915

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