Membrane interactions of the globular domain and the hypervariable region of KRAS4b define its unique diffusion behavior

The RAS proteins are GTP-dependent switches that regulate signaling pathways and are frequently mutated in cancer. RAS proteins concentrate in the plasma membrane via lipid-tethers and hypervariable region side-chain interactions in distinct nano-domains. However, little is known about RAS membrane...

Descripción completa

Detalles Bibliográficos
Autores principales: Goswami, Debanjan, Chen, De, Yang, Yue, Gudla, Prabhakar R, Columbus, John, Worthy, Karen, Rigby, Megan, Wheeler, Madeline, Mukhopadhyay, Suman, Powell, Katie, Burgan, William, Wall, Vanessa, Esposito, Dominic, Simanshu, Dhirendra K, Lightstone, Felice C, Nissley, Dwight V, McCormick, Frank, Turbyville, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060043/
https://www.ncbi.nlm.nih.gov/pubmed/31958057
http://dx.doi.org/10.7554/eLife.47654

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060043/
https://www.ncbi.nlm.nih.gov/pubmed/31958057
http://dx.doi.org/10.7554/eLife.47654

Ejemplares similares