Integrin α6 signaling induces STAT3-TET3-mediated hydroxymethylation of genes critical for maintenance of glioma stem cells

Both the extracellular matrix (ECM) and DNA epigenetic regulation are critical for maintaining stem cell phenotype and cancer progression. Whether and how ECM regulates epigenetic alterations to influence cancer stem cells (CSCs) remain to be explored. Here we report that ECM through laminin-integri...

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Detalles Bibliográficos
Autores principales: Herrmann, Andreas, Lahtz, Christoph, Song, Jieun, Aftabizadeh, Maryam, Cherryholmes, Gregory A., Xin, Hong, Adamus, Tomasz, Lee, Heehyoung, Grunert, David, Armstrong, Brian, Chu, Peiguo, Brown, Christine, Lim, Michael, Forman, Stephen, Yu, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060098/
https://www.ncbi.nlm.nih.gov/pubmed/31819166
http://dx.doi.org/10.1038/s41388-019-1134-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060098/
https://www.ncbi.nlm.nih.gov/pubmed/31819166
http://dx.doi.org/10.1038/s41388-019-1134-6

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