The position of the target site for engineered nucleases improves the aberrant mRNA clearance in in vivo genome editing

Engineered nucleases are widely used for creating frameshift or nonsense mutations in the target genes to eliminate gene functions. The resulting mRNAs carrying premature termination codons can be eliminated by nonsense-mediated mRNA decay. However, it is unclear how effective this process would be...

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Detalles Bibliográficos
Autores principales: Lee, Jae Hoon, Yu, Sungsook, Nam, Tae Wook, Roh, Jae-il, Jin, Young, Han, Jeong Pil, Cha, Ji-Young, Kim, Yoon Ki, Yeom, Su-Cheong, Nam, Ki Taek, Lee, Han-Woong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060192/
https://www.ncbi.nlm.nih.gov/pubmed/32144373
http://dx.doi.org/10.1038/s41598-020-61154-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060192/
https://www.ncbi.nlm.nih.gov/pubmed/32144373
http://dx.doi.org/10.1038/s41598-020-61154-4

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