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The position of the target site for engineered nucleases improves the aberrant mRNA clearance in in vivo genome editing
Engineered nucleases are widely used for creating frameshift or nonsense mutations in the target genes to eliminate gene functions. The resulting mRNAs carrying premature termination codons can be eliminated by nonsense-mediated mRNA decay. However, it is unclear how effective this process would be...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060192/ https://www.ncbi.nlm.nih.gov/pubmed/32144373 http://dx.doi.org/10.1038/s41598-020-61154-4 |