Interplay between DNA damage repair and apoptosis shapes cancer evolution through aneuploidy and microsatellite instability

Driver mutations and chromosomal aneuploidy are major determinants of tumorigenesis that exhibit complex relationships. Here, we identify associations between driver mutations and chromosomal aberrations that define two tumor clusters, with distinct regimes of tumor evolution underpinned by unique s...

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Detalles Bibliográficos
Autores principales: Auslander, Noam, Wolf, Yuri I., Koonin, Eugene V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060240/
https://www.ncbi.nlm.nih.gov/pubmed/32144251
http://dx.doi.org/10.1038/s41467-020-15094-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060240/
https://www.ncbi.nlm.nih.gov/pubmed/32144251
http://dx.doi.org/10.1038/s41467-020-15094-2

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