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Interplay between DNA damage repair and apoptosis shapes cancer evolution through aneuploidy and microsatellite instability
Driver mutations and chromosomal aneuploidy are major determinants of tumorigenesis that exhibit complex relationships. Here, we identify associations between driver mutations and chromosomal aberrations that define two tumor clusters, with distinct regimes of tumor evolution underpinned by unique s...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060240/ https://www.ncbi.nlm.nih.gov/pubmed/32144251 http://dx.doi.org/10.1038/s41467-020-15094-2 |