A Novel System for Functional Determination of Variants of Uncertain Significance using Deep Convolutional Neural Networks

Many drugs are developed for commonly occurring, well studied cancer drivers such as vemurafenib for BRAF V600E and erlotinib for EGFR exon 19 mutations. However, most tumors also harbor mutations which have an uncertain role in disease formation, commonly called Variants of Uncertain Significance (...

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Detalles Bibliográficos
Autores principales: Zimmerman, Lior, Zelichov, Ori, Aizenmann, Arie, Barbash, Zohar, Vidne, Michael, Tarcic, Gabi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060242/
https://www.ncbi.nlm.nih.gov/pubmed/32144301
http://dx.doi.org/10.1038/s41598-020-61173-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060242/
https://www.ncbi.nlm.nih.gov/pubmed/32144301
http://dx.doi.org/10.1038/s41598-020-61173-1

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