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A Novel System for Functional Determination of Variants of Uncertain Significance using Deep Convolutional Neural Networks
Many drugs are developed for commonly occurring, well studied cancer drivers such as vemurafenib for BRAF V600E and erlotinib for EGFR exon 19 mutations. However, most tumors also harbor mutations which have an uncertain role in disease formation, commonly called Variants of Uncertain Significance (...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060242/ https://www.ncbi.nlm.nih.gov/pubmed/32144301 http://dx.doi.org/10.1038/s41598-020-61173-1 |