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Transcription co-activator P300 activates Elk1-aPKC-ι signaling mediated epithelial-to-mesenchymal transition and malignancy in hepatocellular carcinoma

Epithelial-to-mesenchymal transition (EMT) plays an important role in invasion and metastasis of hepatocellular carcinoma (HCC). Our previous study found that atypical protein kinase C-ι (aPKC-ι) promoted the EMT process in HCC. However, how the aPKC-ι signaling pathway is regulated in HCC has not b...

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Detalles Bibliográficos
Autores principales: Ma, Chaoqun, Huang, Shuhong, Xu, Lei, Tian, Li, Yang, Yan, Wang, Jianming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060348/
https://www.ncbi.nlm.nih.gov/pubmed/32144235
http://dx.doi.org/10.1038/s41389-020-0212-5