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Direct observation of ligand migration within human hemoglobin at work

Hemoglobin is one of the best-characterized proteins with respect to structure and function, but the internal ligand diffusion pathways remain obscure and controversial. Here we captured the CO migration processes in the tense (T), relaxed (R), and second relaxed (R2) quaternary structures of human...

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Detalles Bibliográficos
Autores principales: Shibayama, Naoya, Sato-Tomita, Ayana, Ohki, Mio, Ichiyanagi, Kouhei, Park, Sam-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060717/
https://www.ncbi.nlm.nih.gov/pubmed/32071219
http://dx.doi.org/10.1073/pnas.1913663117