Detection of the in vitro modulation of Plasmodium falciparum Arf1 by Sec7 and ArfGAP domains using a colorimetric plate-based assay

The regulation of human Arf1 GTPase activity by ArfGEFs that stimulate GDP/GTP exchange and ArfGAPs that mediate GTP hydrolysis has attracted attention for the discovery of Arf1 inhibitors as potential anti-cancer agents. The malaria parasite Plasmodium falciparum encodes a Sec7 domain-containing pr...

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Detalles Bibliográficos
Autores principales: Swart, Tarryn, Khan, Farrah D., Ntlantsana, Apelele, Laming, Dustin, Veale, Clinton G. L., Przyborski, Jude M., Edkins, Adrienne L., Hoppe, Heinrich C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061341/
https://www.ncbi.nlm.nih.gov/pubmed/32144363
http://dx.doi.org/10.1038/s41598-020-61101-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061341/
https://www.ncbi.nlm.nih.gov/pubmed/32144363
http://dx.doi.org/10.1038/s41598-020-61101-3

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