Cargando…

Head-to-head comparison of in-house produced CD19 CAR-T cell in ALL and NHL patients

BACKGROUND: CD19 chimeric antigen receptor T (CAR-T) cells demonstrate remarkable remission rates in pediatric and adult patients with refractory or relapsed (r/r) acute lymphoblastic leukemia (ALL) and non-Hodgkin's lymphoma (NHL). In 2016, we initiated a clinical trial with in-house produced...

Descripción completa

Detalles Bibliográficos
Autores principales:	Itzhaki, Orit, Jacoby, Elad, Nissani, Abraham, Levi, Michal, Nagler, Arnon, Kubi, Adva, Brezinger, Karin, Brayer, Hadar, Zeltzer, Li-at, Rozenbaum, Meir, Vernitsky, Helly, Markel, Gal, Toren, Amos, Avigdor, Abraham, Schachter, Jacob, Besser, Michal J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Clinical/Translational Cancer Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061891/ https://www.ncbi.nlm.nih.gov/pubmed/32152221 http://dx.doi.org/10.1136/jitc-2019-000148

Ejemplares similares

Impact of cryopreservation on CAR T production and clinical response
por: Brezinger-Dayan, Karin, et al.
Publicado: (2022)

Comparison of non-myeloablative lymphodepleting preconditioning regimens in patients undergoing adoptive T cell therapy
por: Nissani, Abraham, et al.
Publicado: (2021)

Molecular and Functional Signatures Associated with CAR T Cell Exhaustion and Impaired Clinical Response in Patients with B Cell Malignancies
por: Beider, Katia, et al.
Publicado: (2022)

Gamma-Delta CAR-T Cells Show CAR-Directed and Independent Activity Against Leukemia
por: Rozenbaum, Meir, et al.
Publicado: (2020)

P520: POINT OF CARE CD19 CHIMERIC ANTIGEN RECEPTOR (CAR) T-CELLS FOR RELAPSED/REFRACTORY ACUTE MYELOID LEUKEMIA (AML) WITH ABERRANT CD19 ANTIGEN EXPRESSION
por: Danylesko, Ivetta, et al.
Publicado: (2023)

Nicotinamide Inhibits Vasculogenic Mimicry, an Alternative Vascularization Pathway Observed in Highly Aggressive Melanoma
por: Itzhaki, Orit, et al.
Publicado: (2013)

Genetic Modification of Tumor-Infiltrating Lymphocytes via Retroviral Transduction
por: Weinstein-Marom, Hadas, et al.
Publicado: (2021)

Tumor-infiltrating lymphocytes from human prostate tumors reveal anti-tumor reactivity and potential for adoptive cell therapy
por: Yunger, Sharon, et al.
Publicado: (2019)

Selection of Shared and Neoantigen-Reactive T Cells for Adoptive Cell Therapy Based on CD137 Separation
por: Seliktar-Ofir, Sivan, et al.
Publicado: (2017)

Differential regulation of aggressive features in melanoma cells by members of the miR-17-92 complex
por: Greenberg, Eyal, et al.
Publicado: (2014)

Serum CEACAM1 Elevation Correlates with Melanoma Progression and Failure to Respond to Adoptive Cell Transfer Immunotherapy
por: Ortenberg, R., et al.
Publicado: (2015)

Development of Allogeneic NK Cell Adoptive Transfer Therapy in Metastatic Melanoma Patients: In Vitro Preclinical Optimization Studies
por: Besser, Michal J., et al.
Publicado: (2013)

Immune co-culture cell microarray – a feasible tool for high-throughput functional investigation of lymphocyte–cancer interactions
por: Baruch, Erez Nissim, et al.
Publicado: (2020)

Predicting and controlling the reactivity of immune cell populations against cancer
por: Oved, Kfir, et al.
Publicado: (2009)

SOX9 indirectly regulates CEACAM1 expression and immune resistance in melanoma cells
por: Ashkenazi, Shira, et al.
Publicado: (2016)

Regulation of Cancer Aggressive Features in Melanoma Cells by MicroRNAs
por: Greenberg, Eyal, et al.
Publicado: (2011)

A novel immune resistance mechanism of melanoma cells controlled by the ADAR1 enzyme
por: Galore-Haskel, Gilli, et al.
Publicado: (2015)

P1108: HIGH COMPLETE RESPONSE RATE FOLLOWING POINT-OF-CARE ANTI CD19 CAR T-CELL THERAPY IN PATIENTS WITH RELAPSED/REFRACTORY FOLLICULAR LYMPHOMA
por: Fried, S., et al.
Publicado: (2022)

Natural Killer Lysis Receptor (NKLR)/NKLR-Ligand Matching as a Novel Approach for Enhancing Anti-Tumor Activity of Allogeneic NK Cells
por: Markel, Gal, et al.
Publicado: (2009)

Improved CAR-T cell activity associated with increased mitochondrial function primed by galactose
por: Gross, Golda, et al.
Publicado: (2023)

Biomarkers in NHL
por: Malek, Sami N.
Publicado: (2011)

Intercellular Transfer of Oncogenic H-Ras at the Immunological Synapse
por: Rechavi, Oded, et al.
Publicado: (2007)

Novel Anti-Melanoma Immunotherapies: Disarming Tumor Escape Mechanisms
por: Sapoznik, Sivan, et al.
Publicado: (2012)

Evaluation of the clinical impact of bone marrow cultures in current medical practice
por: Sharvit, Gal, et al.
Publicado: (2022)

Regulation of CEACAM1 Protein Expression by the Transcription Factor ETS-1 in BRAF-Mutant Human Metastatic Melanoma Cells()()
por: Kfir-Elirachman, Karin, et al.
Publicado: (2018)

P889: POINT-OF-CARE ANTI-BCMA CAR T-CELL THERAPY INDUCES ENCOURAGING RESPONSE RATES IN HIGH-RISK RELAPSE/REFRACTORY MULTIPLE MYELOMA
por: Magen, Hila, et al.
Publicado: (2023)

P1400: THREE YEARS OUTCOMES OF PRIMARY MEDIASTINAL B CELL LYMPHOMA PATIENTS FOLLOWING ANTI CD19 CAR-T CELL THERAPY - A SINGLE CENTER EXPERIENCE
por: Geva, Mika, et al.
Publicado: (2023)

Stem cell hunt in NHL
por: Merkel, Olaf, et al.
Publicado: (2015)

NHL - Extranodal T-cell lymphoma
por: Devi, Seema, et al.
Publicado: (2015)

Exploring Potential Germline-Associated Roles of the TRIM-NHL Protein NHL-2 Through RNAi Screening
por: Davis, Gregory M., et al.
Publicado: (2017)

TRIM-NHL protein, NHL-2, modulates cell fate choices in the C. elegans germ line
por: Brenner, John L., et al.
Publicado: (2022)

Comparative structural analyses of the NHL domains from the human E3 ligase TRIM–NHL family
por: Chaikuad, Apirat, et al.
Publicado: (2022)

Epigenetic Profiling and Response to CD19 Chimeric Antigen Receptor T-Cell Therapy in B-Cell Malignancies
por: Garcia-Prieto, Carlos A, et al.
Publicado: (2021)

Non-Hodgkin Lymphoma (NHL) in Pakistan
por: Pervez, Shahid
Publicado: (2012)

The TRIM-NHL protein NHL-2 is a co-factor in the nuclear and somatic RNAi pathways in C. elegans
por: Davis, Gregory M, et al.
Publicado: (2018)

Histopathological expression analysis of intercellular adhesion molecule 1 (ICAM-1) along development and progression of human melanoma
por: Galore-Haskel, Gilli, et al.
Publicado: (2017)

Focus on Adoptive T Cell Transfer Trials in Melanoma
por: Hershkovitz, Liat, et al.
Publicado: (2010)

ADAR1-mediated regulation of melanoma invasion
por: Nemlich, Yael, et al.
Publicado: (2018)

Interrelationship between Dendritic Cell Trafficking and Francisella tularensis Dissemination following Airway Infection
por: Bar-Haim, Erez, et al.
Publicado: (2008)

Diagnosis and management of multiple myeloma during pregnancy: case report, review of the literature, and an update on current treatments
por: Magen, Hila, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_aljoe0dgvtll8aftijcbdnkf36