Multiscale modelling of drug transport and metabolism in liver spheroids

In early preclinical drug development, potential candidates are tested in the laboratory using isolated cells. These in vitro experiments traditionally involve cells cultured in a two-dimensional monolayer environment. However, cells cultured in three-dimensional spheroid systems have been shown to...

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Detalles Bibliográficos
Autores principales: Leedale, Joseph A., Kyffin, Jonathan A., Harding, Amy L., Colley, Helen E., Murdoch, Craig, Sharma, Parveen, Williams, Dominic P., Webb, Steven D., Bearon, Rachel N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061947/
https://www.ncbi.nlm.nih.gov/pubmed/32194929
http://dx.doi.org/10.1098/rsfs.2019.0041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061947/
https://www.ncbi.nlm.nih.gov/pubmed/32194929
http://dx.doi.org/10.1098/rsfs.2019.0041

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