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KAP1 targets actively transcribed genomic loci to exert pleomorphic effects on RNA polymerase II activity
KAP1 (KRAB-associated protein 1) is best known as a co-repressor responsible for inducing heterochromatin formation, notably at transposable elements. However, it has also been observed to bind the transcription start site of actively expressed genes. To address this paradox, we characterized the pr...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061982/ https://www.ncbi.nlm.nih.gov/pubmed/32068487 http://dx.doi.org/10.1098/rstb.2019.0334 |