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Stochastic fluctuations in apoptotic threshold of tumour cells can enhance apoptosis and combat fractional killing
Fractional killing, which is a significant impediment to successful chemotherapy, is observed even in a population of genetically identical cancer cells exposed to apoptosis-inducing agents. This phenomenon arises not from genetic mutation but from cell-to-cell variation in the activation timing and...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062090/ https://www.ncbi.nlm.nih.gov/pubmed/32257298 http://dx.doi.org/10.1098/rsos.190462 |