A dual druggable genome-wide siRNA and compound library screening approach identifies modulators of parkin recruitment to mitochondria

Genetic and biochemical evidence points to an association between mitochondrial dysfunction and Parkinson's disease (PD). PD-associated mutations in several genes have been identified and include those encoding PTEN-induced putative kinase 1 (PINK1) and parkin. To identify genes, pathways, and...

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Detalles Bibliográficos
Autores principales: Scott, Helen L., Buckner, Nicola, Fernandez-Albert, Francesc, Pedone, Elisa, Postiglione, Lorena, Shi, Gongyu, Allen, Nicholas, Wong, Liang-Fong, Magini, Lorenzo, Marucci, Lucia, O'Sullivan, Gregory A., Cole, Sarah, Powell, Justin, Maycox, Peter, Uney, James B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Neurobiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062187/
https://www.ncbi.nlm.nih.gov/pubmed/31911436
http://dx.doi.org/10.1074/jbc.RA119.009699

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062187/
https://www.ncbi.nlm.nih.gov/pubmed/31911436
http://dx.doi.org/10.1074/jbc.RA119.009699

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