Prediction of the SARS-CoV-2 (2019-nCoV) 3C-like protease (3CL (pro)) structure: virtual screening reveals velpatasvir, ledipasvir, and other drug repurposing candidates

We prepared the three-dimensional model of the SARS-CoV-2 (aka 2019-nCoV) 3C-like protease (3CL (pro)) using the crystal structure of the highly similar (96% identity) ortholog from the SARS-CoV. All residues involved in the catalysis, substrate binding and dimerisation are 100% conserved. Compariso...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Yu Wai, Yiu, Chin-Pang Bennu, Wong, Kwok-Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062204/
https://www.ncbi.nlm.nih.gov/pubmed/32194944
http://dx.doi.org/10.12688/f1000research.22457.2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062204/
https://www.ncbi.nlm.nih.gov/pubmed/32194944
http://dx.doi.org/10.12688/f1000research.22457.2

Ejemplares similares