Individualized genetic network analysis reveals new therapeutic vulnerabilities in 6,700 cancer genomes

Tumor-specific genomic alterations allow systematic identification of genetic interactions that promote tumorigenesis and tumor vulnerabilities, offering novel strategies for development of targeted therapies for individual patients. We develop an Individualized Network-based Co-Mutation (INCM) meth...

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Detalles Bibliográficos
Autores principales: Liu, Chuang, Zhao, Junfei, Lu, Weiqiang, Dai, Yao, Hockings, Jennifer, Zhou, Yadi, Nussinov, Ruth, Eng, Charis, Cheng, Feixiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062285/
https://www.ncbi.nlm.nih.gov/pubmed/32101536
http://dx.doi.org/10.1371/journal.pcbi.1007701

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062285/
https://www.ncbi.nlm.nih.gov/pubmed/32101536
http://dx.doi.org/10.1371/journal.pcbi.1007701

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