Biophysical mechanisms for QRS- and QTc-interval prolongation in mice with cardiac expression of expanded CUG-repeat RNA

Myotonic dystrophy type 1 (DM1), the most common form of muscular dystrophy in adults, results from the expression of toxic gain-of-function transcripts containing expanded CUG-repeats. DM1 patients experience cardiac electrophysiological defects, including prolonged PR-, QRS-, and QT-intervals, tha...

Descripción completa

Detalles Bibliográficos
Autores principales: Tylock, Kevin M., Auerbach, David S., Tang, Zhen Zhi, Thornton, Charles A., Dirksen, Robert T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062505/
https://www.ncbi.nlm.nih.gov/pubmed/31968060
http://dx.doi.org/10.1085/jgp.201912450

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062505/
https://www.ncbi.nlm.nih.gov/pubmed/31968060
http://dx.doi.org/10.1085/jgp.201912450

Ejemplares similares