Determinants of ion selectivity in ASIC1a- and ASIC2a-containing acid-sensing ion channels

Trimeric acid-sensing ion channels (ASICs) contribute to neuronal signaling by converting extracellular acidification into excitatory sodium currents. Previous work with homomeric ASIC1a implicates conserved leucine (L7′) and consecutive glycine-alanine-serine (GAS belt) residues near the middle, an...

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Detalles Bibliográficos
Autores principales: Lynagh, Timothy, Flood, Emelie, Boiteux, Céline, Sheikh, Zeshan Pervez, Allen, Toby W., Pless, Stephan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062507/
https://www.ncbi.nlm.nih.gov/pubmed/31952079
http://dx.doi.org/10.1085/jgp.201812297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062507/
https://www.ncbi.nlm.nih.gov/pubmed/31952079
http://dx.doi.org/10.1085/jgp.201812297

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