Cargando…

The Toxoplasma gondii virulence factor ROP16 acts in cis and trans, and suppresses T cell responses

The ability of Toxoplasma gondii to inject the rhoptry kinase ROP16 into host cells results in the activation of the transcription factors STAT3 and STAT6, but it is unclear how these events impact infection. Here, parasites that inject Cre-recombinase with rhoptry proteins were used to distinguish...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Longfei, Christian, David A., Kochanowsky, Joshua A., Phan, Anthony T., Clark, Joseph T., Wang, Shuai, Berry, Corbett, Oh, Jung, Chen, Xiaoguang, Roos, David S., Beiting, Daniel P., Koshy, Anita A., Hunter, Christopher A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062521/ https://www.ncbi.nlm.nih.gov/pubmed/31961916 http://dx.doi.org/10.1084/jem.20181757

Ejemplares similares

ROP16-mediated activation of STAT6 enhances cyst development of type III Toxoplasma gondii in neurons
por: Kochanowsky, Joshua A., et al.
Publicado: (2023)

ROP16-Mediated Activation of STAT6 Suppresses Host Cell Reactive Oxygen Species Production, Facilitating Type III Toxoplasma gondii Growth and Survival
por: Kochanowsky, Joshua A., et al.
Publicado: (2021)

The ROP16(III)-dependent early immune response determines the subacute CNS immune response and type III Toxoplasma gondii survival
por: Tuladhar, Shraddha, et al.
Publicado: (2019)

The Polymorphic Pseudokinase ROP5 Controls Virulence in Toxoplasma gondii by Regulating the Active Kinase ROP18
por: Behnke, Michael S., et al.
Publicado: (2012)

Toxoplasma gondii Superinfection and Virulence during Secondary Infection Correlate with the Exact ROP5/ROP18 Allelic Combination
por: Jensen, Kirk D. C., et al.
Publicado: (2015)

Prediction of Toxoplasma gondii virulence factor ROP18 competitive inhibitors by virtual screening
por: Yin, Kun, et al.
Publicado: (2019)

Rhoptry Proteins ROP5 and ROP18 Are Major Murine Virulence Factors in Genetically Divergent South American Strains of Toxoplasma gondii
por: Behnke, Michael S., et al.
Publicado: (2015)

The Rhoptry Pseudokinase ROP54 Modulates Toxoplasma gondii Virulence and Host GBP2 Loading
por: Kim, Elliot W., et al.
Publicado: (2016)

ROP39 is an Irgb10-specific parasite effector that modulates acute Toxoplasma gondii virulence
por: Singh, Shishir, et al.
Publicado: (2023)

Expression and Purification of Recombinant ROP1 of Toxoplasma gondii in Bacteria
por: Mohabati, Reyhaneh, et al.
Publicado: (2013)

ATF6β is a host cellular target of the Toxoplasma gondii virulence factor ROP18
por: Yamamoto, Masahiro, et al.
Publicado: (2011)

ROP18 Is a Key Factor Responsible for Virulence Difference between Toxoplasma gondii and Neospora caninum
por: Lei, Tao, et al.
Publicado: (2014)

Toxoplasma gondii virulence factor ROP1 reduces parasite susceptibility to murine and human innate immune restriction
por: Butterworth, Simon, et al.
Publicado: (2022)

Influenza Virus-Like Particles Presenting both Toxoplasma gondii ROP4 and ROP13 Enhance Protection against T. gondii Infection
por: Kang, Hae-Ji, et al.
Publicado: (2019)

The Rhoptry Proteins ROP18 and ROP5 Mediate Toxoplasma gondii Evasion of the Murine, But Not the Human, Interferon-Gamma Response
por: Niedelman, Wendy, et al.
Publicado: (2012)

IFN-γ stimulated murine and human neurons mount anti-parasitic defenses against the intracellular parasite Toxoplasma gondii
por: Chandrasekaran, Sambamurthy, et al.
Publicado: (2022)

Influence of Two Major Toxoplasma Gondii Virulence Factors (ROP16 and ROP18) on the Immune Response of Peripheral Blood Mononuclear Cells to Human Toxoplasmosis Infection
por: Hernández-de-los-Ríos, Alejandro, et al.
Publicado: (2019)

ROP18 Is a Rhoptry Kinase Controlling the Intracellular Proliferation of Toxoplasma gondii
por: El Hajj, Hiba, et al.
Publicado: (2007)

Protein targets of thiazolidinone derivatives in Toxoplasma gondii and insights into their binding to ROP18
por: Molina, Diego, et al.
Publicado: (2018)

Detection of Toxoplasma gondii Infections using Virus-Like Particles Displaying T. gondii ROP4 Antigen
por: Kim, Min-Ju, et al.
Publicado: (2021)

The Toxoplasma gondii protein ROP2 mediates host organelle association with the parasitophorous vacuole membrane
por: Sinai, Anthony P., et al.
Publicado: (2001)

The secreted kinase ROP17 promotes Toxoplasma gondii dissemination by hijacking monocyte tissue migration
por: Drewry, Lisa L, et al.
Publicado: (2019)

The pathogenicity and virulence of Toxoplasma gondii
por: Sanchez, Syrian G., et al.
Publicado: (2021)

The Orphan Nuclear Receptor TLX Is an Enhancer of STAT1-Mediated Transcription and Immunity to Toxoplasma gondii
por: Beiting, Daniel P., et al.
Publicado: (2015)

Epitope analysis and protection by a ROP19 DNA vaccine against Toxoplasma gondii
por: Zhou, Jian, et al.
Publicado: (2016)

Screening and Identification of the Host Proteins Interacting with Toxoplasma gondii Rhoptry Protein ROP16
por: Pan, Ming, et al.
Publicado: (2017)

Adjuvantic cytokine IL-33 improves the protective immunity of cocktailed DNA vaccine of ROP5 and ROP18 against toxoplasma gondii infection in mice
por: Zhu, Yu-Chao, et al.
Publicado: (2020)

Differential Impacts on Host Transcription by ROP and GRA Effectors from the Intracellular Parasite Toxoplasma gondii
por: Rastogi, Suchita, et al.
Publicado: (2020)

Toxoplasma gondii ROP16(I) Deletion: The Exacerbated Impact on Adverse Pregnant Outcomes in Mice
por: Cui, Wen, et al.
Publicado: (2020)

Toxoplasma gondii virulence prediction using hierarchical cluster analysis based on coding sequences (CDS) of sag1, gra7 and rop18
por: Subekti, Didik T, et al.
Publicado: (2021)

Mucosal Administration of Recombinant Baculovirus Displaying Toxoplasma gondii ROP4 Confers Protection Against T. gondii Challenge Infection in Mice
por: Yoon, Keon-Woong, et al.
Publicado: (2021)

ROP18-Mediated Transcriptional Reprogramming of HEK293T Cell Reveals New Roles of ROP18 in the Interplay Between Toxoplasma gondii and the Host Cell
por: Li, Jie-Xi, et al.
Publicado: (2020)

The transcriptome of Toxoplasma gondii
por: Radke, Jay R, et al.
Publicado: (2005)

Toxoplasma gondii Type-I ROP18 Targeting Human E3 Ligase TRIM21 for Immune Escape
por: Yao, Lijie, et al.
Publicado: (2021)

Protective efficacy of recombinant canine adenovirus type-2 expressing TgROP18 (CAV-2-ROP18) against acute and chronic Toxoplasma gondii infection in mice
por: Li, Xiu-Zhen, et al.
Publicado: (2015)

Transepithelial Migration of Toxoplasma gondii Is Linked to Parasite Motility and Virulence
por: Barragan, Antonio, et al.
Publicado: (2002)

Sequence Variation in Toxoplasma gondii rop17 Gene among Strains from Different Hosts and Geographical Locations
por: Zhang, Nian-Zhang, et al.
Publicado: (2014)

Immune Protection of Rhoptry Protein 21 (ROP21) of Toxoplasma gondii as a DNA Vaccine Against Toxoplasmosis
por: Zhang, Zhenchao, et al.
Publicado: (2018)

Dynamics of the Toxoplasma gondii inner membrane complex
por: Ouologuem, Dinkorma T., et al.
Publicado: (2014)

Secretory traffic in the eukaryotic parasite Toxoplasma gondii : less is more
por: Joiner, Keith A., et al.
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_vmkbflb1l0jrhuujmj2btkjm6f