Isocitrate dehydrogenase 2 protects mice from high-fat diet-induced metabolic stress by limiting oxidative damage to the mitochondria from brown adipose tissue

Isocitrate dehydrogenase 2 (IDH2) is an NADP(+)-dependent enzyme that catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate in the mitochondrial matrix, and is critical for the production of NADPH to limit the accumulation of mitochondrial reactive oxygen species (ROS). Here, we s...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Jae-Ho, Go, Younghoon, Kim, Do-Young, Lee, Sun Hee, Kim, Ok-Hee, Jeon, Yong Hyun, Kwon, Taeg Kyu, Bae, Jae-Hoon, Song, Dae-Kyu, Rhyu, Im Joo, Lee, In-Kyu, Shong, Minho, Oh, Byung-Chul, Petucci, Christopher, Park, Jeen-Woo, Osborne, Timothy F., Im, Seung-Soon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062825/
https://www.ncbi.nlm.nih.gov/pubmed/32015410
http://dx.doi.org/10.1038/s12276-020-0379-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062825/
https://www.ncbi.nlm.nih.gov/pubmed/32015410
http://dx.doi.org/10.1038/s12276-020-0379-z

Ejemplares similares