Isocitrate dehydrogenase 2 protects mice from high-fat diet-induced metabolic stress by limiting oxidative damage to the mitochondria from brown adipose tissue

Isocitrate dehydrogenase 2 (IDH2) is an NADP(+)-dependent enzyme that catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate in the mitochondrial matrix, and is critical for the production of NADPH to limit the accumulation of mitochondrial reactive oxygen species (ROS). Here, we s...

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Detalles Bibliográficos
Autores principales: Lee, Jae-Ho, Go, Younghoon, Kim, Do-Young, Lee, Sun Hee, Kim, Ok-Hee, Jeon, Yong Hyun, Kwon, Taeg Kyu, Bae, Jae-Hoon, Song, Dae-Kyu, Rhyu, Im Joo, Lee, In-Kyu, Shong, Minho, Oh, Byung-Chul, Petucci, Christopher, Park, Jeen-Woo, Osborne, Timothy F., Im, Seung-Soon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062825/
https://www.ncbi.nlm.nih.gov/pubmed/32015410
http://dx.doi.org/10.1038/s12276-020-0379-z

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