Poly(ADP-Ribose)Polymerase (PARP) Inhibitors and Radiation Therapy

Poly(ADP-ribose)polymerase-1 (PARP1) is a DNA repair enzyme highly expressed in the nuclei of mammalian cells, with a structure and function that have attracted interest since its discovery. PARP inhibitors, moreover, can be used to induce synthetic lethality in cells where the homologous recombinat...

Descripción completa

Detalles Bibliográficos
Autores principales: Jannetti, Stephen A., Zeglis, Brian M., Zalutsky, Michael R., Reiner, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062869/
https://www.ncbi.nlm.nih.gov/pubmed/32194409
http://dx.doi.org/10.3389/fphar.2020.00170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062869/
https://www.ncbi.nlm.nih.gov/pubmed/32194409
http://dx.doi.org/10.3389/fphar.2020.00170

Ejemplares similares