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Poly(ADP-Ribose)Polymerase (PARP) Inhibitors and Radiation Therapy
Poly(ADP-ribose)polymerase-1 (PARP1) is a DNA repair enzyme highly expressed in the nuclei of mammalian cells, with a structure and function that have attracted interest since its discovery. PARP inhibitors, moreover, can be used to induce synthetic lethality in cells where the homologous recombinat...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062869/ https://www.ncbi.nlm.nih.gov/pubmed/32194409 http://dx.doi.org/10.3389/fphar.2020.00170 |