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Mitochondria as target to inhibit proliferation and induce apoptosis of cancer cells: the effects of doxycycline and gemcitabine
Doxycycline has anti-tumour effects in a range of tumour systems. The aims of this study were to define the role mitochondria play in this process and examine the potential of doxycycline in combination with gemcitabine. We studied the adenocarcinoma cell line A549, its mitochondrial DNA-less deriva...
Autores principales: | Dijk, Sas N., Protasoni, Margherita, Elpidorou, Marilena, Kroon, Albert M., Taanman, Jan-Willem |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063048/ https://www.ncbi.nlm.nih.gov/pubmed/32152409 http://dx.doi.org/10.1038/s41598-020-61381-9 |
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