Pre-emptive Quality Control of a Misfolded Membrane Protein by Ribosome-Driven Effects

Cells possess multiple mechanisms that protect against the accumulation of toxic aggregation-prone proteins. Here, we identify a pre-emptive pathway that reduces synthesis of membrane proteins that have failed to properly assemble in the endoplasmic reticulum (ER). We show that loss of the ER membra...

Descripción completa

Detalles Bibliográficos
Autores principales: Lakshminarayan, Ramya, Phillips, Ben P., Binnian, Imogen L., Gomez-Navarro, Natalia, Escudero-Urquijo, Norberto, Warren, Alan J., Miller, Elizabeth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063571/
https://www.ncbi.nlm.nih.gov/pubmed/31956032
http://dx.doi.org/10.1016/j.cub.2019.12.060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063571/
https://www.ncbi.nlm.nih.gov/pubmed/31956032
http://dx.doi.org/10.1016/j.cub.2019.12.060

Ejemplares similares