A Positive Feedback Loop of TET3 and TGF-β1 Promotes Liver Fibrosis

Pathological activation of TGF-β signaling is universal in fibrosis. Aberrant TGF-β signaling in conjunction with transdifferentiation of hepatic stellate cells (HSCs) into fibrogenic myofibroblasts plays a central role in liver fibrosis. Here we report that the DNA demethylase TET3 is anomalously u...

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Detalles Bibliográficos
Autores principales: Xu, Yetao, Sun, Xiaoli, Zhang, Ruling, Cao, Tiefeng, Cai, Shi-Ying, Boyer, James L., Zhang, Xuchen, Li, Da, Huang, Yingqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063678/
https://www.ncbi.nlm.nih.gov/pubmed/32023451
http://dx.doi.org/10.1016/j.celrep.2019.12.092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063678/
https://www.ncbi.nlm.nih.gov/pubmed/32023451
http://dx.doi.org/10.1016/j.celrep.2019.12.092

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