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A Positive Feedback Loop of TET3 and TGF-β1 Promotes Liver Fibrosis

Pathological activation of TGF-β signaling is universal in fibrosis. Aberrant TGF-β signaling in conjunction with transdifferentiation of hepatic stellate cells (HSCs) into fibrogenic myofibroblasts plays a central role in liver fibrosis. Here we report that the DNA demethylase TET3 is anomalously u...

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Detalles Bibliográficos
Autores principales:	Xu, Yetao, Sun, Xiaoli, Zhang, Ruling, Cao, Tiefeng, Cai, Shi-Ying, Boyer, James L., Zhang, Xuchen, Li, Da, Huang, Yingqun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063678/ https://www.ncbi.nlm.nih.gov/pubmed/32023451 http://dx.doi.org/10.1016/j.celrep.2019.12.092

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