Genetic and pharmacological targeting of A2a receptor improves function of anti-mesothelin CAR T cells

BACKGROUND: CAR T cell-based therapies have shown promising results in hematological malignancies. Results of CAR T cell projects in solid tumors have been less impressive, and factors including lack of targetable antigens and immunosuppressive tumor microenvironment (TME) have been suggested as cul...

Descripción completa

Detalles Bibliográficos
Autores principales: Masoumi, Elham, Jafarzadeh, Leila, Mirzaei, Hamid Reza, Alishah, Khadijeh, Fallah-Mehrjardi, Keyvan, Rostamian, Hosein, Khakpoor-Koosheh, Mohammad, Meshkani, Reza, Noorbakhsh, Farshid, Hadjati, Jamshid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063771/
https://www.ncbi.nlm.nih.gov/pubmed/32151275
http://dx.doi.org/10.1186/s13046-020-01546-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063771/
https://www.ncbi.nlm.nih.gov/pubmed/32151275
http://dx.doi.org/10.1186/s13046-020-01546-6

Ejemplares similares