Genetic and pharmacological targeting of A2a receptor improves function of anti-mesothelin CAR T cells

BACKGROUND: CAR T cell-based therapies have shown promising results in hematological malignancies. Results of CAR T cell projects in solid tumors have been less impressive, and factors including lack of targetable antigens and immunosuppressive tumor microenvironment (TME) have been suggested as cul...

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Detalles Bibliográficos
Autores principales: Masoumi, Elham, Jafarzadeh, Leila, Mirzaei, Hamid Reza, Alishah, Khadijeh, Fallah-Mehrjardi, Keyvan, Rostamian, Hosein, Khakpoor-Koosheh, Mohammad, Meshkani, Reza, Noorbakhsh, Farshid, Hadjati, Jamshid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063771/
https://www.ncbi.nlm.nih.gov/pubmed/32151275
http://dx.doi.org/10.1186/s13046-020-01546-6

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