Fibroblast-Derived CXCL12 Promotes Breast Cancer Metastasis by Facilitating Tumor Cell Intravasation

The chemokine CXCL12 has been shown to regulate breast tumor growth, however, its mechanism in initiating distant metastasis is not well understood. Here, we generated a novel conditional allele of Cxcl12 in mice and used a fibroblast-specific Cre transgene along with various mammary tumor models to...

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Detalles Bibliográficos
Autores principales: Ahirwar, Dinesh K., Nasser, Mohd W., Ouseph, Madhu M., Elbaz, Mohamad, Cuitiño, Maria C., Kladney, Raleigh D., Varikuti, Sanjay, Kaul, Kirti, Satoskar, Abhay R., Ramaswamy, Bhuvaneswari, Zhang, Xiaoli, Ostrowski, Michael C., Leone, Gustavo, Ganju, Ramesh K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063845/
https://www.ncbi.nlm.nih.gov/pubmed/29720724
http://dx.doi.org/10.1038/s41388-018-0263-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063845/
https://www.ncbi.nlm.nih.gov/pubmed/29720724
http://dx.doi.org/10.1038/s41388-018-0263-7

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