An ultralong CDRH2 in HCV neutralizing antibody demonstrates structural plasticity of antibodies against E2 glycoprotein

A vaccine protective against diverse HCV variants is needed to control the HCV epidemic. Structures of E2 complexes with front layer-specific broadly neutralizing antibodies (bNAbs) isolated from HCV-infected individuals, revealed a disulfide bond-containing CDRH3 that adopts straight (individuals w...

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Detalles Bibliográficos
Autores principales: Flyak, Andrew I, Ruiz, Stormy E, Salas, Jordan, Rho, Semi, Bailey, Justin R, Bjorkman, Pamela J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064334/
https://www.ncbi.nlm.nih.gov/pubmed/32125272
http://dx.doi.org/10.7554/eLife.53169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064334/
https://www.ncbi.nlm.nih.gov/pubmed/32125272
http://dx.doi.org/10.7554/eLife.53169

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