Cargando…

An ultralong CDRH2 in HCV neutralizing antibody demonstrates structural plasticity of antibodies against E2 glycoprotein

A vaccine protective against diverse HCV variants is needed to control the HCV epidemic. Structures of E2 complexes with front layer-specific broadly neutralizing antibodies (bNAbs) isolated from HCV-infected individuals, revealed a disulfide bond-containing CDRH3 that adopts straight (individuals w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Flyak, Andrew I, Ruiz, Stormy E, Salas, Jordan, Rho, Semi, Bailey, Justin R, Bjorkman, Pamela J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Immunology and Inflammation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064334/ https://www.ncbi.nlm.nih.gov/pubmed/32125272 http://dx.doi.org/10.7554/eLife.53169

Ejemplares similares

Computational identification of HCV neutralizing antibodies with a common HCDR3 disulfide bond motif in the antibody repertoires of infected individuals
por: Bozhanova, Nina G., et al.
Publicado: (2022)

Structural Diversity of Ultralong CDRH3s in Seven Bovine Antibody Heavy Chains
por: Dong, Jinhui, et al.
Publicado: (2019)

An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses
por: Liu, Lihong, et al.
Publicado: (2022)

A bovine antibody possessing an ultralong complementarity-determining region CDRH3 targets a highly conserved epitope in sarbecovirus spike proteins
por: Burke, Matthew J., et al.
Publicado: (2022)

Identification and characterization of an unexpected isomerization motif in CDRH2 that affects antibody activity
por: Yi, Meiqi, et al.
Publicado: (2023)

Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants
por: Weisblum, Yiska, et al.
Publicado: (2020)

A broadly neutralizing macaque monoclonal antibody against the HIV-1 V3-Glycan patch
por: Wang, Zijun, et al.
Publicado: (2020)

Antigenic mapping and functional characterization of human New World hantavirus neutralizing antibodies
por: Engdahl, Taylor B, et al.
Publicado: (2023)

Neutralizing activities of caprine antibodies towards conserved regions of the HCV envelope glycoprotein E2
por: El Abd, Yasmine S, et al.
Publicado: (2011)

A potent human neutralizing antibody Fc-dependently reduces established HBV infections
por: Li, Dan, et al.
Publicado: (2017)

Transferring the Characteristics of Naturally Occurring and Biased Antibody Repertoires to Human Antibody Libraries by Trapping CDRH3 Sequences
por: Venet, Sophie, et al.
Publicado: (2012)

A single full-length VAR2CSA ectodomain variant purifies broadly neutralizing antibodies against placental malaria isolates
por: Doritchamou, Justin YA, et al.
Publicado: (2022)

Broadly neutralizing human antibodies against dengue virus identified by single B cell transcriptomics
por: Durham, Natasha D, et al.
Publicado: (2019)

Computational Characterization of the Binding Properties of the HIV1-Neutralizing Antibody PG16 and Design of PG16-Derived CDRH3 Peptides
por: Deubler, Manuel, et al.
Publicado: (2023)

Identifying immunologically-vulnerable regions of the HCV E2 glycoprotein and broadly neutralizing antibodies that target them
por: Quadeer, Ahmed A., et al.
Publicado: (2019)

The human antibody sequence space and structural design of the V, J regions, and CDRH3 with Rosetta
por: Schmitz, Samuel, et al.
Publicado: (2022)

The smallest functional antibody fragment: Ultralong CDR H3 antibody knob regions potently neutralize SARS-CoV-2
por: Huang, Ruiqi, et al.
Publicado: (2023)

Development of antibody-dependent cell cytotoxicity function in HIV-1 antibodies
por: Doepker, Laura E, et al.
Publicado: (2021)

Neutralizing SARS-CoV-2
por: Poeschla, Eric
Publicado: (2020)

B cell overexpression of FCRL5 and PD-1 is associated with low antibody titers in HCV infection
por: Ogega, Clinton O., et al.
Publicado: (2022)

Tackling variants with antibodies
por: Aitken, Elizabeth H, et al.
Publicado: (2022)

LGI1, CASPR2 and related antibodies: a molecular evolution of the phenotypes
por: Binks, Sophie N M, et al.
Publicado: (2018)

Cross-reactive antibodies after SARS-CoV-2 infection and vaccination
por: Grobben, Marloes, et al.
Publicado: (2021)

SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies
por: Fielding, Ceri Alan, et al.
Publicado: (2022)

Access to ultra-long IgG CDRH3 bovine antibody sequences using short read sequencing technology
por: Oyola, Samuel O., et al.
Publicado: (2021)

Diversity in the Cow Ultralong CDR H3 Antibody Repertoire
por: Haakenson, Jeremy K., et al.
Publicado: (2018)

Boosting of cross-reactive antibodies to endemic coronaviruses by SARS-CoV-2 infection but not vaccination with stabilized spike
por: Crowley, Andrew R, et al.
Publicado: (2022)

High-Throughput Sequencing Analysis of Post-Liver Transplantation HCV E2 Glycoprotein Evolution in the Presence and Absence of Neutralizing Monoclonal Antibody
por: Babcock, Gregory J., et al.
Publicado: (2014)

Demonstrative Imaging of Emphysematous Cystitis
por: May, Tal, et al.
Publicado: (2016)

Antibody escape by polyomavirus capsid mutation facilitates neurovirulence
por: Lauver, Matthew D, et al.
Publicado: (2020)

Clinical spectrum of high-titre GAD65 antibodies
por: Budhram, Adrian, et al.
Publicado: (2021)

LGI1 antibody encephalitis: acute treatment comparisons and outcome
por: Rodriguez, Andrew, et al.
Publicado: (2022)

Neuronal antibodies in patients with suspected or confirmed sporadic Creutzfeldt-Jakob disease
por: Rossi, Meghan, et al.
Publicado: (2015)

Panproteome-wide analysis of antibody responses to whole cell pneumococcal vaccination
por: Campo, Joseph J, et al.
Publicado: (2018)

Redefining innate natural antibodies as important contributors to anti-tumor immunity
por: Rawat, Kavita, et al.
Publicado: (2021)

Comprehensive characterization of the antibody responses to SARS-CoV-2 Spike protein finds additional vaccine-induced epitopes beyond those for mild infection
por: Garrett, Meghan E, et al.
Publicado: (2022)

Multicentre comparison of a diagnostic assay: aquaporin-4 antibodies in neuromyelitis optica
por: Waters, Patrick, et al.
Publicado: (2016)

Clinical course, therapeutic responses and outcomes in relapsing MOG antibody-associated demyelination
por: Ramanathan, Sudarshini, et al.
Publicado: (2018)

Intracellular and non-neuronal targets of voltage-gated potassium channel complex antibodies
por: Lang, Bethan, et al.
Publicado: (2017)

Association of human cytomegalovirus (HCMV) neutralizing antibodies with antibodies to the HCMV glycoprotein complexes
por: Shibamura, Miho, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_3idtj0uinq9c5mpp71mrarnbdm