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Distinct regulatory ribosomal ubiquitylation events are reversible and hierarchically organized

Activation of the integrated stress response (ISR) or the ribosome-associated quality control (RQC) pathway stimulates regulatory ribosomal ubiquitylation (RRub) on distinct 40S ribosomal proteins, yet the cellular role and fate of ubiquitylated proteins remain unclear. We demonstrate that uS10 and...

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Detalles Bibliográficos
Autores principales: Garshott, Danielle M, Sundaramoorthy, Elayanambi, Leonard, Marilyn, Bennett, Eric J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064338/
https://www.ncbi.nlm.nih.gov/pubmed/32011234
http://dx.doi.org/10.7554/eLife.54023