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Fatal amyloid formation in a patient’s antibody light chain is caused by a single point mutation
In systemic light chain amyloidosis, an overexpressed antibody light chain (LC) forms fibrils which deposit in organs and cause their failure. While it is well-established that mutations in the LC’s V(L) domain are important prerequisites, the mechanisms which render a patient LC amyloidogenic are i...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064341/ https://www.ncbi.nlm.nih.gov/pubmed/32151314 http://dx.doi.org/10.7554/eLife.52300 |