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Caliciviral protein-based artificial translational activator for mammalian gene circuits with RNA-only delivery

Synthetic RNA-based gene circuits enable sophisticated gene regulation without the risk of insertional mutagenesis. While various RNA binding proteins have been used for translational repression in gene circuits, the direct translational activation of synthetic mRNAs has not been achieved. Here we d...

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Detalles Bibliográficos
Autores principales: Nakanishi, Hideyuki, Saito, Hirohide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064597/
https://www.ncbi.nlm.nih.gov/pubmed/32157083
http://dx.doi.org/10.1038/s41467-020-15061-x