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In Vivo Assay Reveals Microbial OleA Thiolases Initiating Hydrocarbon and β-Lactone Biosynthesis

OleA, a member of the thiolase superfamily, is known to catalyze the Claisen condensation of long-chain acyl coenzyme A (acyl-CoA) substrates, initiating metabolic pathways in bacteria for the production of membrane lipids and β-lactone natural products. OleA homologs are found in diverse bacterial...

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Detalles Bibliográficos
Autores principales: Smith, Megan D., Robinson, Serina L., Molomjamts, Mandkhai, Wackett, Lawrence P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064751/
https://www.ncbi.nlm.nih.gov/pubmed/32156808
http://dx.doi.org/10.1128/mBio.00111-20