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Substrate Flexibility of the Flavin‐Dependent Dihydropyrrole Oxidases PigB and HapB Involved in Antibiotic Prodigiosin Biosynthesis

In the biosynthesis of the tripyrrolic pigment prodigiosin, PigB is a predicted flavin‐dependent oxidase responsible for the formation of 2‐methyl‐3‐amylpyrrole (MAP) from a dihydropyrrole. To prove which dihydropyrrole is the true intermediate, both possibilities, 5‐methyl‐4‐pentyl‐3,4‐dihydro‐2H‐p...

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Detalles Bibliográficos
Autores principales: Couturier, Maxime, Bhalara, Hiral D., Chawrai, Suresh R., Monson, Rita, Williamson, Neil R., Salmond, George P. C., Leeper, Finian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065143/
https://www.ncbi.nlm.nih.gov/pubmed/31433555
http://dx.doi.org/10.1002/cbic.201900424