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Substrate Flexibility of the Flavin‐Dependent Dihydropyrrole Oxidases PigB and HapB Involved in Antibiotic Prodigiosin Biosynthesis
In the biosynthesis of the tripyrrolic pigment prodigiosin, PigB is a predicted flavin‐dependent oxidase responsible for the formation of 2‐methyl‐3‐amylpyrrole (MAP) from a dihydropyrrole. To prove which dihydropyrrole is the true intermediate, both possibilities, 5‐methyl‐4‐pentyl‐3,4‐dihydro‐2H‐p...
Autores principales: | Couturier, Maxime, Bhalara, Hiral D., Chawrai, Suresh R., Monson, Rita, Williamson, Neil R., Salmond, George P. C., Leeper, Finian J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065143/ https://www.ncbi.nlm.nih.gov/pubmed/31433555 http://dx.doi.org/10.1002/cbic.201900424 |
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